发明名称 |
INHIBITORS OF BRUTON'S TYROSINE KINASE |
摘要 |
This application discloses compounds according to generic Formula (I): wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are useful for the treatment of oncological, auto-immune, and inflammatory diseases caused by aberrant B-cell activation. Also disclosed are compositions containing compounds of Formula (I) and at least one carrier, diluent or excipient. |
申请公布号 |
CA2929747(A1) |
申请公布日期 |
2015.06.18 |
申请号 |
CA20142929747 |
申请日期 |
2014.12.10 |
申请人 |
F. HOFFMANN-LA ROCHE AG;CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
LOPEZ-TAPIA, FRANCISCO JAVIER;SO, SUNG-SAU;QIAO, QI;DOMINIQUE, ROMYR |
分类号 |
C07D401/14;A61K31/4155;A61K31/4439;A61P11/06;A61P29/00;C07D403/06;C07D403/14;C07D409/14 |
主分类号 |
C07D401/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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