SorCS1 FOR USE IN THE TREATMENT OF OBESITY AND OVERWEIGHT

摘要

The present invention relates to SorCS1-like agents, including SorCS1, nucleic acid molecule encoding expression of SorCS1 and fragments thereof, as well as vectors containing said nucleic acid and to cells expressing SorCS1 and said fragments, for use in a method of reducing appetite, and/or for promoting weight loss, and/or for treating obesity, and/or for increasing metabolism, and/or for increasing thermogenesis, and/or for converting white fat into brown fat

主权项

1. An agent selected from the group consisting of:
a) an isolated polypeptide comprising:
i) the amino acid sequence of SEQ ID NOs: 15; orii) a biologically active sequence variant of the amino acid sequence of i) wherein the variant has at least 60% sequence identity to said SEQ ID NO: 15,iii) a biologically active fragment of at least 15 contiguous amino acids of any one of i) through ii), said fragment having at least 60% sequence identity to SEQ ID NO: 15 in a range of overlap of at least 15 amino acids, b) a nucleic acid sequence encoding a polypeptide as defined in a); c) a vector comprising the nucleic acid molecule as defined in b), d) an isolated host cell transformed or transduced with the nucleic acid of b) or the vector of c), for use in a method for reducing appetite, and/or for treating obesity, and/or for promoting weight loss, and/or increasing metabolism, and/or increasing thermogenesis, and/or converting white fat into brown fat.