发明名称 |
MODIFIED SERPINS FOR THE TREATMENT OF BLEEDING DISORDERS |
摘要 |
This invention relates pro-coagulant serpin molecules engineered by modification of the P4, P2, P1 and/or P1' residues within the reactive center loop (RCL) to display increased specificity for anticoagulant proteases. These modified serpin molecules may be useful in therapy, for example as pro-coagulants for the treatment of bleeding. |
申请公布号 |
CA2933508(A1) |
申请公布日期 |
2015.06.18 |
申请号 |
CA20142933508 |
申请日期 |
2014.12.15 |
申请人 |
CAMBRIDGE ENTERPRISE LIMITED |
发明人 |
HUNTINGTON, JAMES ANDREW;POLDERDIJK, STEPHANIE;BAGLIN, TREVOR |
分类号 |
C07K14/81 |
主分类号 |
C07K14/81 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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