发明名称 STABILIZED FORMULATIONS CONTAINING ANTI-NGF ANTIBODIES
摘要 <p>The present invention provides a method for maintaining the stability of an antibody in a formulation, comprising: storing an antibody formulation for six months or more at 51C or more; wherein the antibody formulation comprises: (i) about 0.1 to 100 mg/ml of a human antibody that specifically binds to human nerve growth factor (hNGF), wherein the antibody comprises a heavy chain and light chain variable region (HCVR / LCVR) amino acid sequence pairs selected from the group consisting of: (i) SEQ ID NOs: 20/22; and (ii) SEQ ID NOs: 4/12; (ii) about 0.01 to 1.0% of a polysorbate 20; (iii) about 1 to 20% of sucrose; and (iv) about 1 mM to about 50 mM acetate; whereby the stored formulation maintains stability such that 90% or more of the antibody is detected by size-exclusion high-performance liquid chromatography (SE-HPLC).</p>
申请公布号 AU2015202886(A1) 申请公布日期 2015.06.18
申请号 AU20150202886 申请日期 2015.05.27
申请人 REGENERON PHARMACEUTICALS, INC. 发明人 WALSH, SCOTT;POTOCKY, TERRA;DIX, DANIEL;SIVENDRAN, RENUKA
分类号 C07K16/22;A61K39/395 主分类号 C07K16/22
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