| 摘要 |
<p>PROBLEM TO BE SOLVED: To provide compositions and methods of use of anti-pancreatic cancer antibodies or fragments thereof, such as murine, chimeric, humanized or human PAM4 antibodies which show some novel and useful therapeutic properties such as binding with high specificity to a pancreatic cancer or other cancers, but not to a normal or benign pancreatic tissues, and binding to an initial pancreatic cancer with a high percentage.SOLUTION: The invention provides a composition for the treatment of cancers such as a pancreatic cancer, in which the antibodies, such as PAM4 antibodies, bind to a PAM4 antigen that shows unique cell and tissue distributions compared with other known antibodies such as CA19.9, DUPAN2, SPAN1, Nd2, B72.3, and Leand Le(y) antibodies that bind to the Lewis antigens.</p> |
