PROCESS FOR CREATING CARBON-CARBON BONDS USING CARBONYL COMPOUNDS

摘要

The present invention concerns a process for preparing a compound of formula (I) by reaction between a compound of formula (II) and a compound of formula (III) in the presence of a copper-containing catalyst, a ligand and base. The invention also concerns the implementing of this process for the preparation of building blocks to prepare molecules of interest in particular in the pharmaceutical, agro-chemical fields, etc.;

主权项

1. A process for preparing a compound of formula (I) by reaction between a compound of formula (II) and a compound of formula (III) in the presence of a copper-containing catalyst, a ligand and a basewhere:
R1 is:
a hydrogen atom;a straight-chain or branched alkyl group having 1 to 15 carbon atoms;a straight-chain or branched alkenyl group having 1 to 15 carbon atoms and comprising at least one double bond;a substituted or unsubstituted aryl group having 6 to 10 carbon atoms;a substituted or unsubstituted heteroaryl group having 5 to 10 members including at least one heteroatom selected in particular from among a nitrogen atom or oxygen atom; R2 is:
a straight-chain or branched alkyl group having 1 to 15 carbon atoms;a straight-chain or branched alkenyl group having 1 to 15 carbon atoms and comprising at least one double bond;a substituted or unsubstituted aryl group having 6 to 10 carbon atoms;a substituted or unsubstituted heteroaryl group having 5 to 10 members including at least one heteroatom selected in particular from among a nitrogen atom or oxygen atom; R3 is:
a substituted or unsubstituted vinyl group;a substituted or unsubstituted aryl group having 6 to 10 carbon atoms;a substituted or unsubstituted heteroaryl group having 5 to 10 members including at least one heteroatom selected in particular from among a nitrogen atom or oxygen atom; X is a halogen atom selected from among fluorine, chlorine, bromine or iodine, a tosylate group or mesylate group.