COMPOUND AND PHOTOACOUSTIC IMAGING CONTRAST MEDIUM CONTAINING THE COMPOUND

摘要

The present invention provides a photoacoustic imaging contrast medium which exhibits a high degree of accumulation into a tumor even when some extent of time has passed after performing administration and which facilitates an increase in the intensity of photoacoustic signal produced by the tumor.;A compound produced by covalent-bonding of an organic dye which absorbs light in the near-infrared wavelength region and a PEG having a branch.

主权项

1. A compound represented by any one of formula (1) to formula (6): wherein, in the formula (1), A1 represents an organic dye which absorbs light in a near-infrared wavelength region, L1 represents a linker part which is any one of —NH—, —CO—, —O—, and —S— or which contains at least one of —NH—, —CO—, —O—, and —S—, q represents an integer of 1 to 5, m and n represent independently an integer of 10 or more and 2,500 or less, and R1 and R2 represent independently an alkyl group having 1 to 5 carbon atoms, wherein, in the formula (2), A1 represents an organic dye which absorbs light in the near-infrared wavelength region, L1 represents a linker part which is any one of —NH—, —CO—, —O—, and —S— or which contains at least one of —NH—, —CO—, —O—, and —S—, p and q represent independently an integer of 1 to 5, 1, m, and n represent independently an integer of 10 or more and 2,500 or less, and R1 and R2 represent independently an alkyl group having 1 to 5 carbon atoms, wherein, in the formula (3), A1 represents an organic dye which absorbs light in the near-infrared wavelength region, L1 represents a linker part which is any one of —NH—, —CO—, —O—, and —S— or which contains at least one of —NH—, —CO—, —O—, and —S—, q represents an integer of 1 to 5, 1, m, and n represent independently an integer of 10 or more and 2,500 or less, and R1 and R2 represent independently an alkyl group having 1 to 5 carbon atoms, wherein, in the formula (4), A1 and A2 represent independently an organic dye which absorbs light in the near-infrared wavelength region, L1 and L2 represent independently a linker part which is any one of —NH—, —CO—, —O—, and —S— or which contains at least one of —NH—, —CO—, —O—, and —S—, p, q, and r represent independently an integer of 1 to 5, m and n represent independently an integer of 10 or more and 2,500 or less, and R1 and R2 represent independently an alkyl group having 1 to 5 carbon atoms, wherein, in the formula (5), A1, A2, A3, and A4 represent independently an organic dye which absorbs light in the near-infrared wavelength region, L1, L2, L3, and L4 represent independently a linker part which is any one of —NH—, —CO—, —O—, and —S— or which contains at least one of —NH—, —CO—, —O—, and —S—, p and q represent independently an integer of 1 to 5, and n represents an integer of 10 or more and 2,500 or less, and wherein, in the formula (6), A1 represents an organic dye which absorbs light in the near-infrared wavelength region, L1 represents a linker part which is any one of —NH—, —CO—, —O—, and —S— or which contains at least one of —NH—, —CO—, —O—, and —S—, p and q represent independently an integer of 1 to 5, and n represents an integer of 10 or more and 2,500 or less.