COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT

摘要

Compounds having activity as phosphate transport inhibitors, more specifically, inhibitors of intestinal apical membrane Na/phosphate co-transport, are disclosed. The compounds have the following structure (I):;;including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein X, Y, R1 and R2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

主权项

1. A pharmaceutical composition comprising: a compound of structure (I):or a stereoisomer or pharmaceutically acceptable salt thereof,
wherein:
X is substituted aryl or substituted heteroaryl;Y is halogen, optionally substituted alkylamino, optionally substituted alkoxy, optionally substituted thioalkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted aryl, —O(optionally substituted cycloalkyl), —O(optionally substituted heterocyclyl) or —O(optionally substituted aryl);each R1 is, independently, hydrogen, halogen, C1-6alkyl or C1-6haloalkyl; andR2 is hydrogen or optionally substituted C1-6alkyl; anda pharmaceutically acceptable carrier, diluent, or excipient.