IMAGING SYSTEM FOR INTRA-OPERATIVE AND POST-OPERATIVE BLOOD PERFUSION MONITORING

摘要

Embodiments described herein generally relate to devices, methods and systems for determining blood oxygenation. By applying near infrared radiation of an appropriate wavelength to the tissue and determining the absorbance at a plurality of points where the distance between the source of the near infrared radiation and the detector are known, the oxygenation state of the hemoglobin can be determined based on position in a three dimensional space.

主权项

1. An imaging device, comprising:
a near infrared spectroscopy (NIRS) device comprising:
a support comprising a first surface;a plurality of radiation sources positioned in connection with the first surface;a plurality of radiation detectors positioned in connection with the first surface, a processor in connection with the near infrared spectroscopy device; and a non-transitory memory adapted to store a plurality of machine-readable instructions which, when executed by the processor, cause the imaging device to:
create a volumetric map, the dimensions of the volumetric map corresponding to the tissue portion;subdivide the volumetric map into volumetric subregions, the volumetric subregions comprising a plurality of voxels, each voxel being assigned either preassigned values or random values;overlay a sensitivity map onto the volumetric map, the sensitivity map having a photon migration pattern;perform at least one iterative cycle, the iterative cycle comprising:
determining the measurement array and the calculated array for the volumetric map, the measurement array comprising optical measurements corresponding to the photon migration pattern, the calculated array comprising determined measurements corresponding to the assigned value as weighted by the photon migration pattern;increasing an assigned value of a test voxel of the volumetric map, each of the test voxel being selected from the voxels of the volumetric subregions, the increase perturbing the volumetric map;calculating perturbed determined measurements of a perturbed calculated array for the volumetric map; anddetermining an error between the measurement array and the perturbed calculated array of the volumetric map, wherein a transformation is applied locally to the test voxel and incorporates the error; andrepeat the iterative cycle until either a preset maximum is reached or the measurement error is less than a present threshold.