发明名称 |
Methods and Compositions for Treating or Diagnosing Melanoma |
摘要 |
Methods and compositions are provided for treating melanoma in a mammalian subject by reducing, inhibiting or down-regulating tumor-associated macrophage (TAM) production or activity in the subject. The methods can involve a combination of reducing macrophage production and number while administering an anti-cancer therapy. The treatment can involve the combined blocking or down-regulating of the nucleic acid or protein expression or activity, or the downstream pathway of CCL-2; with the blocking or down-regulating of the nucleic acid or protein expression or activity, or the downstream pathway of a matrix metalloprotease (e.g., MMP9). Another aspect involves blocking the expression or activity of VEGF. Another aspect involves blocking or down-regulating the expression, activity or signaling of the MAPK pathway or the PI3K-AKT-mTOR pathway. |
申请公布号 |
US2015166646(A1) |
申请公布日期 |
2015.06.18 |
申请号 |
US201314407607 |
申请日期 |
2013.03.15 |
申请人 |
The Wistar Institute of Anatomy and Biology |
发明人 |
Wang Tao;Herlyn Meenhard;Kaufman Russel E. |
分类号 |
C07K16/24;A61K39/395;A61K31/437;G01N33/574;A61K31/4045;A61K31/519;C12N5/0786;C12Q1/68;C07K16/22;A61K31/505 |
主分类号 |
C07K16/24 |
代理机构 |
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代理人 |
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主权项 |
1. A composition comprising an agent, ligand or compound that inhibits or down-regulates macrophage production or activity in the subject for use in the treatment of melanoma. |
地址 |
Philadelphia PA US |