FORTIFIED MICRONUTRIENT SALT FORMULATIONS

摘要

Salt formulations, which are resistant to moisture and cooking conditions, are described herein. The formulations provide particles of micronutrients and vitamins encapsulated within heat resistant pH-sensitive water-insoluble polymers, which are packaged within a salt shell. The pH-sensitive, water-insoluble, thermally stable materials stabilize the micronutrients, particularly at high temperatures, such as during food preparation and cooking, and release the micronutrients at the desired locations such as the stomach, small intestine, etc. Preferred pH-sensitive polymers release at a low pH, less than the pH present in the stomach. The particles can be used to deliver daily-recommended doses of micronutrients simultaneously with salt, eliminating the need for vitamin pills. This is particularly important in populations suffering from severe malnutrition.

主权项

1. A salt formulation comprising:
particles comprising one or more therapeutic agents, prophylactic agents, nutraceutical agents, diagnostic agents, or combinations thereof a matrix formed of inert excipient having the particles dispersed therein, a pH-sensitive polymer coating on the outer surface of, or surrounding, the matrix, wherein the polymer coating is resistant to permeation of water into the matrix and provides release of the particles upon exposure to a defined pH, and a coating of one or more salts on the pH-sensitive polymer coating, wherein the formulation is stable up to one hour at 100° C.