PROCESS FOR THE PRODUCTION OF AN ABUSE-PROOFED DOSAGE FORM

摘要

The present invention relates to a process for the production of abuse-proofed, thermoformed dosage forms containing, apart from one or more active ingredients with potential for abuse and optionally physiologically acceptable auxiliary substances, at least one synthetic or natural polymer with a breaking strength of at least 500 N.

主权项

1. A process for the production of a solid pharmaceutical dosage forms with at least reduced potential for abuse, comprising:
a) a formulation mixture containing at least one active ingredient with potential for abuse, at least one synthetic or natural polymer (C), which exhibits a breaking strength of at least 500 N, and optionally auxiliary substances (B) is shaped into formed articles by application of force, b) the formed articles are optionally singulated and optionally in each case graded by size and, c) after or during heating at least to the softening point of the polymer (C), the formed articles are exposed to force until they have a breaking hardness of at least 500 N, and optionally provided with a cover and all the formed articles are optionally mixed back together again.