| 发明名称 |
Drug formulations using water soluble antioxidants |
| 摘要 |
<p>The present invention relates to solid, semisolid, or liquid formulations comprising water soluble antioxidants that prevent or reduce formic acid and/or formyl species generation in the dosage form during the manufacturing process and/or during shelf-life storage. The formulations of the present invention prevent or reduce formation of N-formyl impurities (and gelatin crosslinking) during the manufacturing process and/or during shelf-life storage.</p> |
| 申请公布号 |
AU2011295837(B2) |
申请公布日期 |
2015.06.18 |
| 申请号 |
AU20110295837 |
申请日期 |
2011.09.01 |
| 申请人 |
BRISTOL-MYERS SQUIBB COMPANY;ASTRAZENECA UK LIMITED |
发明人 |
NARANG, AJIT;RAO, VENKATRAMANA M.;DESAI, DIVYAKANT S. |
| 分类号 |
A61K9/20;A61K9/28;A61K9/32;A61K9/34;A61K9/36;A61K31/155;A61K31/403;A61K47/02;A61K47/10;A61K47/12;A61K47/14 |
主分类号 |
A61K9/20 |
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