POLY((LACTIC-CO-GLYCOLIC ACID)-B-LYSINE) AND PROCESS FOR SYNTHESIZING A BLOCK COPOLYMER OF PLGA AND PLL (POLY-E-CBZ-L-LYSINE)

摘要

A method of synthesizing copolymers is provided. The method can include coupling a degradable polymer to a poly(amino acid) and then deprotecting the copolymer if the poly(amino acid) contains protected side chains. Copolymer compositions are provided. These compositions include PLGA-PLL copolymers, PLGA-PLL-cbz copolymers, and copolymers of a polyester with a carboxylic acid end group coupled to a poly(amino acid) with an amine group. The compositions may include therapeutic blends and formulations of copolymers.

主权项

1. A method of synthesizing a copolymer comprising:
coupling a degradable polymer to a poly(amino acid) containing protected side chains by combining the degradable polymer, the poly(amino acid), a solvent, and a coupling catalyst to form a copolymer solution having copolymer; isolating the copolymer to form an isolated copolymer; dissolving the isolated copolymer in a deprotecting solvent and forming a thin film by removing at least a portion of the deprotecting solvent; adding a deprotecting agent to form a deprotected copolymer; and isolating the deprotected copolymer.