| 摘要 |
PROBLEM TO BE SOLVED: To provide novel specific binding molecules, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize neoepitopes of disease-associated proteins which derive from native endogenous proteins but are prevalent in the body of a patient in a variant form and/or out of their normal physiological context.SOLUTION: The invention relates to a method for extracting a novel specific binding molecule by subjecting a sample obtained from a patient who is symptom-free, or who is clinically unusually stable, but who is affected with or at risk of developing a disorder to a specimen of pathologically altered cells or tissues with predetermined pathological characteristics, and identifying a binding molecule which binds to the specimen but not to corresponding cells or tissues without such pathological characteristics as it may be derived from a healthy subject. |
