发明名称 BETA-LACTAMASE SUBSTRATES AND METHODS OF THEIR USE FOR THE DIAGNOSIS OF TUBERCULOSIS
摘要 β-Lactamase substrates and methods for using the substrates to detect β-lactamase diagnose tuberculosis.
申请公布号 US2015167048(A1) 申请公布日期 2015.06.18
申请号 US201314401775 申请日期 2013.05.15
申请人 The Texas A&M University System ;The Board of Trustees of the Leland Stnaford Junior University 发明人 Rao Jianghong;Cirillo Jeffrey D.;Xie Hexin;Sacchettini James C.
分类号 C12Q1/34;C07D501/57 主分类号 C12Q1/34
代理机构 代理人
主权项 1. A compound having the formula: or an ester or a salt thereof, wherein A is selected from the group consisting of: (a) substituted and unsubstituted C6-C10 aryl; and(b) substituted and unsubstituted C3-C7 heteroaryl; R1 is selected from the group consisting of: (a) methoxy; and(b) ethoxy; R2 is selected from the group consisting of hydrogen, C1-C3 alkyl, C1-C3 alkyl substituted with one or more halogens, and substituted piperazine; X is O or S; Ra, Rb, Rc, and Rd are independently selected from the group consisting of hydrogen, halogen, nitro, C1-C3 alkyl, and C1-C3 alkyl substituted with one or more halogens; Z is a reporting group that provides an optical signal when released from the compound; and n is 0 or 1.
地址 College Station TX US