SURFACE MODIFIED MULTI-RESPONSIVE NANOCONTAINERS IN DIFFERENT STIMULUS FOR SPECIFIC DRUG DELIVERY SYSTEMS FOR TARGETED THERAPY

摘要

The present invention proposes the development of technology in the domain of targeted therapy and local drug delivery to the affected area of the tumor. H invention relates to surface modification nanocontainers (shperes of organic and inorganic polymers), which are sensitive to acidic environment, elevated temperature (T approx 41-43 degrees of Celsius), redox potential as well as the application of external applied magnetic field. These nanocontainers are made suitable to be able to carry drugs, such as antibiotics, anti-cancer, cytostatic and antimicrobials and their release will be carried to the patient tissue due to the prevailing conditions. The composition of nanocontainers based on organic and inorganic polymers which exhibit sensitivity to the aforementioned conditions. The adjustment is carried out through the surface with aminosilanes or amino acids as ligands or small molecules such maleamide molecules which can undergo nucleophilic addition and further binding of targeting molecule.