COMPOSITIONS AND METHODS FOR INHIBITION OF CATHEPSINS

摘要

The disclosure is directed to compound of Formula I and methods of using these compounds in the treatment of conditions in which modulation of a cathepsin, particularly cathepsin K or cathepsin L, will be therapeutically useful. In another implementation, the disclosure provides a method of inhibiting a neoplasm, comprising administering to a patient suffering from such neoplasm an amount of the compound effective to treat the neoplasm. In other implementations, the compounds described herein can be used to treat non-neoplastic conditions such as osteoporosis, viral infections and parasites, particularly protozoal parasites.