USE OF STING AGONISTS TO TREAT CHRONIC HEPATITIS B VIRUS INFECTION
摘要
Provided herein are methods of treating a subject having hepatitis B viral (HBV) infection. More specifically, disclosed herein are methods of stimulating the innate cytokine response in macrophages, dendritic cells and/or liver non-parenchymal cells with small molecular agonists of STING to suppress HBV replication in hepatocytes. The methods are especially suitable for use in the treatment of chronic HBV infections. Also disclosed herein are methods of identifying compounds useful in the treatment of HBV infection.
申请公布号
WO2015061294(A3)
申请公布日期
2015.06.18
申请号
WO2014US61536
申请日期
2014.10.21
申请人
PHILADELPHIA HEALTH & EDUCATION CORPORATION D/B/A/