发明名称 |
HUMAN MONOCLONAL ANTIBODIES BROADLY PROTECTIVE AGAINST INFLUENZA B VIRUS AND METHODS OF USING THE SAME |
摘要 |
Materials and methods are provided for treating influenza B infections in humans. Anti-human influenza virus monoclonal antibodies and antigen-binding fragments thereof having a neutralization activity against a human influenza B virus are provided. Methods for producing anti-human influenza B virus monoclonal antibodies are also provided. The antibodies and antigen-binding fragments thereof can be effective against a wide range of influenza B viral strains. Methods of inhibiting or treating a human influenza B infection are provided. The anti-influenza B therapeutics can also be used to manufacture medicaments effective against influenza B infections, to detect human influenza B in a human subject, for use in pharmaceutical compositions, and for use in kits for at least one of the prevention, the treatment, and the detection of human influenza B in a human subject. |
申请公布号 |
EP2814841(A4) |
申请公布日期 |
2015.06.17 |
申请号 |
EP20130744084 |
申请日期 |
2013.01.31 |
申请人 |
OSAKA UNIVERSITY;THE RESEARCH FOUNDATION FOR MICROBIAL DISEASES OFOSAKA UNIVERSITY;MEDICAL AND BIOLOGICAL LABORATORIES CO., LTD.;DEPARTMENT OF MEDICAL SCIENCES |
发明人 |
YASUGI, MAYO;KUHARA, MOTOKI;BOON-LONG, JOTIKA;FUJIYAMA, KAZUHITO;KOKETSU, RITSUKO;IKUTA, KAZUYOSHI |
分类号 |
C07K16/10;A61K39/00;A61K39/395;A61P31/16;C12N15/02;C12P21/08;G01N33/569 |
主分类号 |
C07K16/10 |
代理机构 |
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