High levels of EMT-TFs for the diagnosis of cancer, in particular of colorectal (CRC) and pancreatic (PC) cancer

摘要

The present invention concerns a method for determining if a subject is affected by a colorectal or pancreatic cancer or for determining the stage, the remission or the progression of a colorectal cancer by measuring the presence of a panel of mRNAs encoding for transcription factors involved in epithelial to mesenchymal transition in a biological sample, wherein mRNA levels of TWIST1, SLUG and ZEB2 genes, are indicative of diagnosis or of partial or full remission of colorectal cancer, and/or colorectal cancer stage variation and/or treatment responsiveness. The invention concerns also kits to work the method.