发明名称 |
Controlled release oral tablet having a unitary core |
摘要 |
<p>Metformin or a pharmaceutically acceptable salt thereof for use in providing continuous and non-pulsating plasma levels of an antihyperglycemic drug with a peak plasma level within 8-12 hours after administration when administered with or shortly after the evening meal in a controlled release pharmaceutical tablet exhibiting the following dissolution profile when tested in a USP type 2 apparatus at 75 rpm in 900 ml of simulated intestinal fluid (pH 7.5 phosphate buffer) and at 37 °C:
- after 2 hours 0-25% of the drug is released;
- after 4 hours 10-45% of the drug is released;
- after 8 hours 30-90% of the drug is released;
- after 12 hours not less than 50% of the drug is released;
- after 16 hours not less than 60% of the drug is released; and
- after 20 hours not less than 70% of the drug is released.</p> |
申请公布号 |
EP2087889(B1) |
申请公布日期 |
2015.06.17 |
申请号 |
EP20090006402 |
申请日期 |
1999.03.19 |
申请人 |
ANDRX PHARMACEUTICALS, INC. |
发明人 |
CHENG, XIU XIU;CHEN, CHIH-MING;JAN, STEVE;CHOU, JOSEPH |
分类号 |
A61K31/155;A61K9/00;A61K9/20;A61K9/22;A61K9/28;A61K9/52;A61P3/10 |
主分类号 |
A61K31/155 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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