３−アルコキシ−４，５−ジアリールチオフェン−２−カルボキサミドの誘導体、この調製およびこの治療的使用

摘要

The invention relates to compounds of the formula (I), where: R1 is: a -NR5R6 group; an unsubstituted or substituted phenyl; R2 is: a (C1-C4)alkyl; an -X-R7 group; R3 and R4 each are independently a substituted phenyl; R5 is a hydrogen atom or a (C1-C4)alkyl; R6 is an unsubstituted or substituted (C1-C4)alkyl; or R5 and R6 together with the nitrogen atom to which they are bonded constitute an unsubstituted or substituted heterocyclic compound; X is a (C1-C5)alkylene; R7 is an -OR8 group, a -NR9R10 group, an -SO2-(C1-C4)alkyl group; R8 is a hydrogen atom or a (C1-C4)alkyl; R9 is a hydrogen atom or a (C1-C4)alkyl; R10 is a hydrogen atom, a -COR11 group, an -SO2R11 group or a -CO(CH2)mOH group; R11 is an unsubstituted or substituted (C1-C4)alkyl; m is 1, 2 or 3. The invention also relates to methods for preparing same and to the therapeutic use thereof.