发明名称 |
INHIBITION OF ANTIMICROBIAL TARGETS WITH REDUCED POTENTIAL FOR RESISTANCE |
摘要 |
The application describes targets and methods that can inhibit bacterial growth in Gram-positive and Gram-negative bacteria. A bacterial enzyme, 2-epimerase, is common to both Gram-positive and Gram-negative bacteria and contains an allosteric site that can be targeted to disrupt the enzyme. The allosteric site is present on the bacterial 2-epimerase, but the analogous mammalian enzyme does not contain the allosteric site, providing a route for attacking bacterial infections without affecting the mammalian enzyme. |
申请公布号 |
EP2882756(A2) |
申请公布日期 |
2015.06.17 |
申请号 |
EP20130828087 |
申请日期 |
2013.08.08 |
申请人 |
AVACYN PHARMACEUTICALS INC.;THE ROCKEFELLER UNIVERSITY |
发明人 |
FISCHETTI, VINCENT, A.;GOLDBERG, ALLAN, R.;SCHUCH, RAYMOND |
分类号 |
C07D513/04;A61K31/4166;A61P31/04;C07D233/96;C07D235/28;C07D239/66;C07D403/04;C07D403/06;C07D405/06;C07D405/14;C07D409/06;C07D413/12;C07D417/04;C07D417/06;C07D417/14;C12Q1/533 |
主分类号 |
C07D513/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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