发明名称 |
PROCESS FOR THE PREPARATION OF PEMETREXED AND LYSIN SALT THEREOF |
摘要 |
The present invention refers to a process for the synthesis of pemetrexed and salts thereof, in particular to a lysine salt thereof, to said salt as such and to pharmaceutical compositions that comprise the same. Furthermore, the present disclosure also relates to a crystalline form of the synthesis intermediate pemetrexed diethyl ether and a crystalline form of the pemetrexed lysine salt. |
申请公布号 |
EP2882753(A1) |
申请公布日期 |
2015.06.17 |
申请号 |
EP20130777144 |
申请日期 |
2013.08.08 |
申请人 |
BERLIN-CHEMIE AG |
发明人 |
BONACCORSI, FABRIZIO;CALVANI, FEDERICO;PASQUI, FRANCO |
分类号 |
C07D487/04;A61K31/519;A61P35/00 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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