发明名称 |
Selection system for eukaryotic cell culture based on a membrane-bound folate receptor gene |
摘要 |
The present invention relates to a novel selection system for use in a eukaryotic cell culture process and for expression of a recombinant product of interest. The selection system is based on the introduction of an exogenous functional membrane-bound folate receptor gene together with the polynucleotide or gene encoding the product of interest into a eukaryotic cell and can be widely utilized with eukaryotic cells for which cellular viability is dependent upon folic acid uptake. |
申请公布号 |
EP2227549(B1) |
申请公布日期 |
2015.06.17 |
申请号 |
EP20080865304 |
申请日期 |
2008.12.19 |
申请人 |
NOVARTIS AG |
发明人 |
ASSARAF, YEHUDA G.;JOSTOCK, THOMAS;KNOPF, HANS-PETER |
分类号 |
C12N15/85;C07K14/705;C12N5/16 |
主分类号 |
C12N15/85 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|