发明名称 |
NUCLEIC ACID FRAGMENT BINDING TO TARGET PROTEIN |
摘要 |
An object of the present invention is to develop and provide a method for efficiently producing a nucleic acid aptamer, particularly, a DNA aptamer, having higher specificity and binding activity against a target substance than those of nucleic acid aptamers obtained by conventional methods. The present invention provides a transcribable or replicable nucleic acid aptamer comprising a natural nucleotide and a non-natural nucleotide having an artificial base-pairable artificial base. The present invention also provides a method for sequencing a non-natural nucleotide-containing single-stranded nucleic acid molecule selected from a single-stranded nucleic acid library. |
申请公布号 |
EP2781599(A4) |
申请公布日期 |
2015.06.17 |
申请号 |
EP20120850348 |
申请日期 |
2012.11.15 |
申请人 |
RIKEN;TAGCYX BIOTECHNOLOGIES |
发明人 |
HIRAO, ICHIRO;HIRAO, MICHIKO;YAMASHIGE, RIE;YOKOYAMA, SHIGEYUKI |
分类号 |
C12N15/115;A61K31/7115;A61K48/00;A61P9/00;A61P43/00;C07H21/02;C07H21/04;C12N9/00;C12Q1/68;C40B40/06;G01N33/15;G01N33/50;G01N33/53 |
主分类号 |
C12N15/115 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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