发明名称 |
PROCESS FOR THE MANUFACTURE OF ISAVUCONAZOLE OR RAVUCONAZOLE |
摘要 |
The invention relates to a process for the manufacture of diastereomerically and enantiomerically enriched triazole compounds isavuconazole and ravuconazole, comprising a Reformatsky reaction between a ketone and a 2-halozincpropionate ester, followed by a resolution step, preferably an enzymatic resolution with an esterase enzyme. |
申请公布号 |
EP2882723(A1) |
申请公布日期 |
2015.06.17 |
申请号 |
EP20130747999 |
申请日期 |
2013.07.31 |
申请人 |
BASILEA PHARMACEUTICA AG |
发明人 |
VAN SUMMEREN, RUBEN;VAESSEN, HARRIE;MINK, DANIEL;WASER, MARIO |
分类号 |
C07D249/08 |
主分类号 |
C07D249/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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