| 发明名称 | Mutations in the BCR-ABL tyrosine kinase associated with resistance to STI-571 | ||
| 摘要 | The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS. | ||
| 申请公布号 | US9056924(B2) | 申请公布日期 | 2015.06.16 |
| 申请号 | US200812080596 | 申请日期 | 2008.04.04 |
| 申请人 | The Regents of the University of California | 发明人 | Sawyers Charles L.;Gorre Mercedes E.;Shah Neil Pravin;Nicoll John |
| 分类号 | C12Q1/00;C07K14/82;C12Q1/48;C12Q1/68 | 主分类号 | C12Q1/00 |
| 代理机构 | Ropes & Gray LLP | 代理人 | Ropes & Gray LLP ;Haley, Jr. James F.;Li Qianru |
| 主权项 | 1. A method of detecting the presence of a cancer cell that is resistant to treatment with STI-571 in a sample from an individual, comprising: (a) obtaining a sample from the individual; and (b) detecting the presence of an isoleucine in a Bcr-Abl polypeptide in the sample at the amino acid position corresponding to amino acid position 315 of SEQ ID NO: 1, wherein the presence of the isoleucine indicates that the sample contains a cancer cell that is resistant to treatment with STI-571, the method of detecting comprising the step of: determining the nucleotide sequence of at least the codon encoding the amino acid residue of the Bcr-Abl polypeptide at the position corresponding to amino acid position 315 of SEQ ID NO: 1. | ||
| 地址 | Oakland CA US | ||