<i>Mycoplasma hyopneumoniae </i>avirulent adjuvanted live vaccine

摘要

Provided are immunogenic and vaccine compositions and methods for their preparation and use, which compositions are effective in protecting against, minimizing the severity of, preventing, and/or ameliorating M. hyopneumoniae infection. Administration to an animal of one or two doses of an adjuvanted live avirulent M. hyopneumoniae composition disclosed herein is effective in providing immunity to the animal and protection from infection with a virulent strain of M. hyopneumoniae thereby reducing the severity of and/or preventing disease caused by one or more virulent strain of M. hyopneumoniae. Also provided are compositions, which further comprise one or more antigen such as, for example, one or more live bacteria, bacterin, toxoid, and/or virus and/or viral antigen. Exemplified are immunogenic compositions, comprising an adjuvanted live avirulent M. hyopneumoniae and compositions, comprising Porcine Circovirus Type 1-Type 2 chimera modified live vaccine (cPCV1-2) in further combination with an adjuvanted live avirulent M. hyopneumoniae.

主权项

1. A composition for eliciting an anti-Mycoplasma hyopneumoniae immune response in an animal, said composition comprising an immunologically effective amount of a live avirulent strain of Mycoplasma hyopneumoniae wherein the live avirulent strain of Mycoplasma hyopneumoniae is a J strain having ATCC accession number 25934 or an isolate thereof whose genome comprises a nucleic acid sequence having at least 95% homology to the nucleic acid sequence of SEQ ID NO.1 and the biologically acceptable adjuvant SP-Oil.