Prosthetic heart valve formation

摘要

A prosthetic heart valve includes a base and a plurality of polymeric leaflets. Each leaflet has a root portion coupled to the base, and each leaflet has an edge portion substantially opposite the root portion and movable relative to the root portion to coapt with a respective edge portion of at least one of the other leaflets of the plurality of leaflets. Each leaflet includes) at least two polymers along at least one portion of the leaflet, and each leaflet has a composition gradient of each of the at least two polymers along at least one portion of the leaflet.

主权项

1. A prosthetic heart valve comprising:
a base; a plurality of polymeric leaflets, each leaflet having a root portion coupled to the base, each leaflet having an edge portion opposite the root portion and movable relative to the root portion to coapt with a respective edge portion of at least one of the other leaflets of the plurality of leaflets, each leaflet comprising at least two polymers, and each leaflet having a composition gradient of each of the at least two polymers along at least one portion of the leaflet, wherein each of the at least two polymers has respective hard segments and soft segments and the ratio of hard segments to soft segments in one of the at least two polymers is higher than the ratio of hard segments to soft segments in another of the at least two polymers, wherein each of the at least two polymers is a respective block polymer, wherein the soft segments of each block polymer is a copolymer of a first monomer and a second monomer and the comonomer ratio of the first monomer to the second monomer is varied in combination with the hard segment to soft segment ratio, wherein the first monomer is dimethyl siloxane and the second monomer is hexamethylene carbonate.