Substituted 2,3,5,9,9B-pentaazacyclopenta[a]naphthalenes and uses thereof

摘要

The present invention is directed to pyridine compounds of Formula (I). Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds as therapeutic agents treating neurological and psychiatric disorders.;

主权项

1. A compound of Formula I: wherein each X1, X2, and X3 is independently CR3 and X4 is N; wherein R1 is C1-C6 alkyl, C3-C6cycloalkyl, tetrahydropyranyl, benzyl, phenyl and pyridyl, in which the benzyl, phenyl and pyridyl is optionally substituted with one or more halogen, CN, C1-C4 alkyl, C1-C4 fluoroalkyl, C1-C4 alkoxy, or C1-C4 fluoroalkoxy; wherein R2 is C1-C4 alkyl or C3-C6 cycloalkyl; and wherein R3 is hydrogen, halogen, CN, —CO2H, —CONH2, —CON(C1-C4 alkyl)2, CHO, C1-C4 alkyl, C1-C4 fluoroalkyl, a cyclic amino containing heterocycle, C2-C4 alkenyl, C2-C4 alkynyl, C1-C4 alkoxy, or C1-C4 fluoroalkoxy; or a pharmaceutically acceptable salt thereof.