Precision-guided nanoparticle systems for drug delivery

摘要

A method of preparing multifunctionalized nanoparticles involves using a modular system of half-linkers to attach functional moieties that serve to deliver the nanoparticles to a desired target, exert an effect at the target, or track the nanoparticles within a cell or an animal. The modular chemistry of the half-linker system permits the custom design and synthesis of functionalized nanoparticles bearing multiple groups and therefore results in precise delivery to desired cell types and intracellular locations. The functionalized nanoparticles can be used to treat or diagnose a variety of medical conditions, including neoplastic diseases, infectious diseases, and chronic diseases.

主权项

1. A set of functionalized nanoparticles for the diagnosis or treatment of a medical condition, each nanoparticle comprising two or more distinct sets of functional moieties, each set of functional moieties comprising a distinct functional moiety covalently attached to the nanoparticle by a distinct linker, wherein each linker comprises a first half-linker and a second half-linker; wherein the first half-linker is covalently bound to the nanoparticle through a first reactive group on the first half-linker, and is covalently bound to a third reactive group on the second half-linker through a second reactive group on the first half-linker, and the second half-linker is covalently bound to the functional moiety through a fourth reactive group on the second half-linker; wherein the second reactive group and third reactive group react as a cross-reacting pair to form the linker; and wherein each set of functional moieties comprises a distinct cross-reacting pair of second and third reactive groups, wherein the functional moieties are selected from the group consisting of a tracking moiety, a delivery moiety, and an effector moiety; and wherein said distinct functional moieties are present on the nanoparticles in a compositional stoichiometry whose variance is less than 5% over the set of functionalized nanoparticles.