| 发明名称 | Composition for regulation of liver X receptor | ||
| 摘要 | The present invention provides a composition for the regulation of Liver X Receptor (LXR) in a cell, and the composition comprises fucoxanthin and its metabolite, fucoxanthinol. The composition of the present invention regulates the transactivation activity of LXR in cell, and antagonizes the transactivation activity of LXRα and/or LXRβ induced by LXR agonists. In other aspects, the present invention also provides a method of regulating a liver X receptor. The composition for the regulation of liver X receptor and the application thereof according to the present invention can regulate the transactivation activity of LXR in cell, and can further be used as alternatives for LXR agonist or antagonist, or supplements, for enhancing LXR-related symptoms. | ||
| 申请公布号 | US9056091(B1) | 申请公布日期 | 2015.06.16 |
| 申请号 | US201414305209 | 申请日期 | 2014.06.16 |
| 申请人 | NATIONAL TAIWAN UNIVERSITY | 发明人 | Huang Ching-jang;Wu Meng-ting;Chou Hong-nong;Chang Mei-ling |
| 分类号 | C07D303/00;A61K31/336;A61K31/18;A61K31/195 | 主分类号 | C07D303/00 |
| 代理机构 | WPAT, P.C. | 代理人 | WPAT, P.C. ;King Anthony |
| 主权项 | 1. A method of regulating a liver X receptor (LXR), comprising administering to a subject an effective amount of fucoxanthin or fucoxanthinol, and the fucoxanthin or the fucoxanthinol regulates the transactivation activity of the liver X receptor; wherein the fucoxanthin is a compound of Formula I:and wherein the fucoxanthinol is a compound of Formula II: | ||
| 地址 | Taipei TW | ||