| 主权项 |
1. A compound according to formula (IIIa), (IIIb) or (IIIc):wherein
R11 is independently H or C1-4 alkyl, L-R or L-CS; L is a covalent linkage that is linear or branched, cyclic or heterocyclic saturated or unsaturated, having 1-16 non hydrogen atoms such that the linkage contains any combination of ester, acid, amine, amide, alcohol, ether, thioether or halide groups or single, double, triple or aromatic carbon-carbon bond; R is a reactive group; CS is a conjugated substance selected from the group consisting of solid supports, resin particles, beads, assay plates, proteins, nucleotides, polynucleotides, enzyme substrates, antibodies, nanobodies, polypeptides, polypeptide-based toxins, amino acids, lipids, carbohydrates, haptens, drugs, ion-complexing agents, microparticles, polymers, cells, viruses, fluorophores, chloroalkanes, and cyanobenzothiazoles; R2 and R16 can be independently H, alkyl, aryl, heteroaryl, CO2H, SO3H, L-CO2H, L-SO3H, L-R or L-CS; R3 and R4 are H, alkyl, L-R, L-CS, L-CO2H, L-SO3H or together form a carbocyclic, aryl, heteroaryl, or heterocyclic ring; alternatively, R2 and R3 and independently R4 and R16 together form a carbocyclic, heterocyclic, aryl or heteroaryl ring; R5, R12, R13, R14 and R15 are independently H, alkyl, aryl, heteroaryl, CO2H, SO3H, L-CO2H, L-SO3H, L-R or L-CS; R20, R21, R22 and R23 are independently H or C1-6 alkyl or one or more of R20 and R21, R21 and R22, R22 and R23, together form an aryl, heteroaryl, carbocyclic or heterocyclic ring; R11 and R12 may together form a carbocyclic, heterocyclic, aryl or heteroaryl ring; R6-10 are independently H, F, Cl, Br, I, OH, alkyl, aryl, heteroaryl, CO2H, SO3H, L-CO2H, L-SO3H, L-R or L-CS; X is CHR23, O, S or NR30; and R30 is H, C1-4 alkyl or —C(O)C1-4 alkyl. |
