Indazole and pyrazolopyridine compounds as CCR1 receptor antagonists

摘要

Disclosed are CCR1 receptor antagonists of the formula (I);
wherein Ar1, Ar2, R1, X and G are disclosed herein. Also disclosed are compositions, methods of making and using compounds of the formula (I).

主权项

1. A compound of the formula (I)wherein
X is nitrogen or, C—R2; Ar1 is carbocycle, heteroaryl or heterocyclyl each optionally substituted by one to three Ra; Ar2 is carbocycle, heteroaryl or heterocyclyl, each optionally substituted by one to three Rb; Cyclic G is cyclopropyl or cyclobutyl each optionally substituted by one to two Rg; R1 is hydrogen, C1-6 alkyl or C1-6 alkoxyC1-6 alkyl; R2 is hydrogen or Ra; Ra is C1-6 alkyl, C3-10 cycloalkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 alkylsulfonyl, C1-6 alkoxycarbonyl, amino, mono-or di-C1-6 alkylamino, C3-6 cycloalkylamino, C1-6 alkylaminocarbonyl, C1-6 acyl, C1-6 acylamino, C1-6 dialkylaminocarbonyl, hydroxyl, halogen, cyano, nitro, oxo, R3—S(O)m—NH—, R3—NH—S(O)m—, aryl or carboxyl; Rb is hydroxyl, carboxyl, halogen, —(CH2)n—CN, —(CH2)n—CO2C1-6alkyl, nitro, —SO3H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, C1-6 alkoxy, C1-6alkylC(O)—, —(CH2)n—NRcRd, R3—S(O)m(CH2)0-1—, R3—S(O)m—NRe—, R3—NRe—S(O)m(CH2)0-1—, —NRf—C(O)—Re, —(CH2)y—C(O)—(CH2)n—NRcRd, heterocyclyl, aryl or heteroaryl, each Rb where possible is optionally halogenated or substituted with 1 to 3 C1-6 alkyl, hydroxyl, C1-6 acyl, C1-6 alkoxycarbonyl, C1-6 alkyl-S(O)m—, aryl or carboxyl; each Rc, Rd are independently hydrogen, C1-6 alkyl, C1-6 acyl, C3-10 cycloalkyl, C1-6 alkoxy, hydroxyC1-6 alkyl, cyano-C1-6 alkyl, C1-6 alkylC1-6 alkoxy, C1-6 alkylsulfonyl, C1-6 alkoxycarbonylC0-3alkyl, C1-6 alkoxycarbonylC3-10cycloalkyl, —(CH2)n—C(O)—NReRf or —(CH2)n—NReRf; each Re, Rf are independently hydrogen, C1-6 alkyl, C3-10 cycloalkyl, C1-6 alkoxy, C1-6 alkoxyC1-6alkyl, mono-or diC1-6alkylaminoC1-6alkyl, hydroxyC1-6 alkyl or C1-6 acyl; Rg is C1-6 alkyl, wherein the C1-6 alkyl is optionally partially or fully halogenated, C2-6 alkenyl, carbocycle, C1-6 alkoxy, carbocyclyl-C1-6 alkoxy, carbocyclyl-C1-6 alkyl, hydroxyC1-6 alkyl, hydroxyl, —(CH2)n—CO2C1-6 alkyl or oxo; R3 is hydrogen, C1-6 alkyl, C3-6cycloalkyl, heterocyclyl(CH2)0-1, mono-or di-C1-6 alkylamino, mono-or di-1-6alkylamino(CH2)2-3N(Re)—, aryl or heteroaryl each optionally substituted with 1 to 3 C1-6 alkyl, C3-6cycloalkyl, C1-6alkoxy, halogen, hydroxyl, oxo, carboxyl, —C(O)NReRf, amino, mono-or di-C1-6 alkylamino, C1-6 alkoxycarbonyl or C1-6 acylamino; each n, y are independently 0-3; each m is independently 0-2; or a pharmaceutically acceptable salt thereof.