发明名称 Methods for treating or preventing cancer and neurodegenerative diseases
摘要 Provided are methods of treating or preventing a neurodegenerative disease comprising administering to a subject having a neurodegenerative disease an effective amount of a compound of Formula I:; where X, R1, R2, subscript m, subscript n and subscript v are as defined herein.
申请公布号 US9056857(B2) 申请公布日期 2015.06.16
申请号 US200913140741 申请日期 2009.12.21
申请人 SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH 发明人 Zhu Lei;Li Yueming
分类号 A61K31/55;A61K31/381;C07D409/12;A61K31/5513;C07D333/34 主分类号 A61K31/55
代理机构 Choate, Hall & Stewart LLP 代理人 Choate, Hall & Stewart LLP
主权项 1. A method for treating a cancer selected from the group consisting of brain cancer, leukemia, bone and connective tissue sarcomas, breast cancer, adrenal cancer, thyroid cancer, pancreatic cancer, pituitary cancer, eye cancer, vaginal cancer, vulvar cancer, cervical cancer, uterine cancer, ovarian cancer, esophageal cancer, stomach cancer, colon cancer, rectal cancer, liver cancer, gallbladder cancer, cholangiocarcinomas, lung cancer, testicular cancer, prostate cancer, penile cancer, oral cancer, basal cancer, salivary gland cancer, pharynx cancer, skin cancer, kidney cancer, Wilms' tumor, bladder cancer, myxosarcoma, osteogenic sarcoma, endotheliosarcoma, lymphangioendotheliosarcoma, mesothelioma, synovioma, hemangioblastoma, epithelial carcinoma, cystadenocarcinoma, bronchogenic carcinoma, sweat gland carcinoma, sebaceous gland carcinoma, or papillary carcinoma and papillary adenocarcinomas, comprising administering to a subject in need of treatment of the cancer an effective amount of a compound of Formula I, having any one of the following structures: or a pharmaceutically acceptable salt thereof.
地址 New York NY US