| 发明名称 | LPA<sub>2 </sub>receptor-specific benzoic acid derivatives | ||
| 摘要 | Disclosed are compounds effective for inhibiting cellular apoptosis and for protecting cells and tissues from the apoptotic effects of chemotherapeutic agents and/or ionizing radiation. Compounds of the invention act as agonists of the LPA2 receptor. Compounds of the invention comprise non-lipid benzoic acid derivatives. | ||
| 申请公布号 | US9056835(B2) | 申请公布日期 | 2015.06.16 |
| 申请号 | US201314011739 | 申请日期 | 2013.08.27 |
| 申请人 | The University of Tennessee Research Foundation | 发明人 | Patil Renukadevi;Fells James;Miller Duane D.;Tigyi Gabor |
| 分类号 | C07D221/14;C07D417/06 | 主分类号 | C07D221/14 |
| 代理机构 | Proskauer Rose LLP | 代理人 | Zheng Lihua;Proskauer Rose LLP |
| 主权项 | 1. A compound of Formula I wherein A is R is H or substituted or unsubstituted phenyl; R1, R2, R3, R4, R5, and R6 are independently H, NO2, Br, Cl, or OCH3; B is C2 to C8 alkyl or alkenyl; and C is optionally substituted with F, Cl, Br, NO2, NH2, OCH3, CH3, CO2H, or phenyl. | ||
| 地址 | Memphis TN US | ||