| 发明名称 |
Process for forming amorphous atorvastatin |
| 摘要 |
A process for forming amorphous atorvastatin comprising the steps of dissolving atorvastatin in a non-hydroxylic solvent and removing the solvent by freeze-drying, as well as processes of dissolving atorvastatin in a hydroxylic solvent with a solubilizing agent or an alkalizing agent or an antioxidant and removing the solvent by freeze-drying to afford amorphous atorvastatin. |
| 申请公布号 |
US9056831(B2) |
申请公布日期 |
2015.06.16 |
| 申请号 |
US201414176081 |
申请日期 |
2014.02.08 |
| 申请人 |
Pfizer Inc. |
发明人 |
deBettencourt, III Antone John;Rose Peter Robert;Shalaev Evgenyi;Quallich George Joseph;Ziegler Carl Bernard |
| 分类号 |
C07D207/00;A61K31/40;C07D207/34;A61K9/14;A61K9/19 |
主分类号 |
C07D207/00 |
| 代理机构 |
|
代理人 |
Tinney Francis J. |
| 主权项 |
1. The process for forming amorphous atorvastatin comprising:
(a) dissolving atorvastatin in a hydroxylic solvent containing an antioxidant selected from the group consisting of: a chelating agent; a free-radical scavenger, and an oxygen scavenger, or mixture thereof; and (b) lyophilizing the solution to afford said amorphous atorvastatin. |
| 地址 |
New York NY US |
