| 发明名称 |
2-ADAMANTYL-BUTYRAMIDE DERIVATIVES AS SELECTIVE 11.BETA.-HSD1 INHIBITORS |
| 摘要 |
<p>The present invention relates to 2-adamantyl-butyramide derivatives of formula I as selective inhibitors of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11.beta.-HSD-1) and the use of such compounds for the treatment and prevention of metabolic syndrome, diabetes, insulin resistance, obesity, lipid disorders, glaucoma, osteoporosis, cognitive disorders, anxiety, depression, immune disorders, hypertension and other diseases and conditions.</p> |
| 申请公布号 |
CA2673430(C) |
申请公布日期 |
2015.06.16 |
| 申请号 |
CA20072673430 |
申请日期 |
2007.11.22 |
| 申请人 |
MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG |
发明人 |
ROCHE, DIDIER;CARNIATO, DENIS;DOARE, LILIANE;CHARON, CHRISTINE;LERICHE, CAROLINE |
| 分类号 |
C07C233/06;A61K31/16;A61K31/19;A61K31/194;A61K31/41;A61K31/4245;A61K31/426;A61K31/4402;A61K31/4453;C07C233/08;C07C233/13;C07C233/15;C07C233/23;C07C233/26;C07C235/22 |
主分类号 |
C07C233/06 |
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