Methods and compositions using miR-3151 in the diagnosis and treatment of cancer

摘要

Compositions comprising therapeutic oligonucleotide compounds that target the expression of genes associated with tumorigenesis or cell transformation are provided. Methods are described to manipulate and treat the oncogenic deregulation of the TP53-associated apoptosis pathway. Markers for acute myeloid leukemia (AML) and uses thereof are described.

主权项

1. A method of treating a subject having or suspected of having a cancer having an increased expression of miR-3151, the method comprising:
administering to the subject an effective amount of a miR-3151 inhibitor sufficient to modulate expression of miR-3151, wherein the levels of miR-3151 are decreased after administration, thereby treating the subject; wherein the cancer is cytogenetically normal acute myeloid leukemia (CN-AML).