Thiolactone antibiotics

摘要

This invention provides a compound having the structure;wherein R1 is H,;whereinn and q are independently an integer from 0 to 8;A is absent or present and when present is;wherein m is an integer from 0 to 8;R3 is an amino, alkyl, aryl, heteroaryl, diol, piperazine, morpholine, piperidine, triazole, azide or biphenyl, each with or without substitution, branched or unbranched, or;andR4 is alkyl, aryl, or heteroaryl, each with or without substitution, branched or unbranched,R2 is H, CH3, or alkyl, aryl, heteroaryl, pyrrole, diazole, or triazole, each with or without substitution, branched or unbranched, or;whereinn and q are independently an integer from 0 to 8;A is absent or present and when present is;and
R6 is azide, methoxy, trifluoromethyl, biphenyl, substituted phenyl, substituted triazole, or alkyl, aryl or heteroaryl, with or without substitution, branched or unbranched,when R1 is H then R2 is other than H or CH3, and when R2 is H or CH3 then R1 is other than H,or a pharmaceutically acceptable salt thereof.

主权项

1. A compound having the structure wherein R1 is H, whereinn and q are independently an integer from 0 to 8;A is absent or present and when present is wherein m is an integer from 0 to 8;R3 is an amino, alkyl, aryl, heteroaryl, diol, piperazine, morpholine, piperidine, triazole, azide or biphenyl, each with or without substitution, branched or unbranched, or andR4 is alkyl, aryl, or heteroaryl, each with or without substitution, branched or unbranched, R2 is H, alkyl, aryl, heteroaryl, pyrrole, diazole, or triazole, each with or without substitution, or whereinn and q are independently an integer from 0 to 8;A is present and when present is R6 is azide, methoxy, trifluoromethyl, biphenyl, substituted phenyl, substituted triazole, or alkyl, aryl or heteroaryl, with or without substitution, branched or unbranched, orA is absent; andR6 is azide, methoxy, trifluoromethyl, biphenyl, substituted phenyl, substituted triazole, aryl or heteroaryl, when R1 is H then R2 is other than H, and when R2 is H, then R1 is other than H, or a pharmaceutically acceptable salt thereof.