发明名称 |
Composição de liberação pulsátil de sildenafil e processo para prepará-la |
摘要 |
<p>The present invention relates to a pulsed-release sildenafil pharmaceutical composition comprising an immediate release fraction containing from 5 to 100 mg of sildenafil and a controlled release fraction containing from 25 to 150 mg of sildenafil, wherein the controlled release fraction consists of particles containing (a) a superdisintegrant agent (b) a coating comprising at least one pH-dependent solubility polymer and at least one pH-independent solubility polymer and (c) optionally, other pharmaceutical excipients. The composition of the present invention exhibits a faster dissolution profile in alkaline media than in acid media, which allows for obtaining enhanced pulsed-release formulations.</p> |
申请公布号 |
BRPI0823356(A2) |
申请公布日期 |
2015.06.16 |
申请号 |
BR2008PI23356 |
申请日期 |
2008.12.12 |
申请人 |
SIEGFRIED RHEIN, S.A. DE C.V. |
发明人 |
ESTEBAN ALEJANDRO FIORE |
分类号 |
A61K31/519;A61K9/54;A61P15/10 |
主分类号 |
A61K31/519 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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