Negative dead volume syringe

摘要

A negative dead volume syringe comprising a body defining a chamber, a syringe tip disposed at a distal end of the chamber and having a tip passageway therethrough in open communication with the chamber, a rod extending from a first end within the chamber to a second end coupleable to a motor to produce bidirectional motion of the rod, and a plunger tip having a proximal portion coupled to the first end of the rod, a medial portion distally extending from said proximal portion and shaped to complement the tip passageway, and a tip extension distally extending from said medial portion and shaped to be received within a dead volume defined by a passageway of a valve coupleable to the syringe tip wherein the plunger tip ensures evacuation of fluid and air from the chamber, syringe tip, and dead volume of the valve upon distal displacement of the rod.

主权项

1. A syringe plunger tip for a syringe, said syringe plunger tip comprising:
a proximal plunger tip portion coupled to a plunger rod drivable to distally and proximally slide said proximal plunger tip portion within a chamber of a body of a syringe, the chamber being defined by an interior of a sidewall of the body of the syringe, said sidewall axially-extending between an open distal end and an open proximal end of the body of the syringe; a medial plunger tip portion coupled to and slideable with said proximal plunger tip portion, said medial plunger tip portion shaped complemental to an open ended passageway defined by an internal sidewall of a syringe tip coupled to the open distal end of the body of the syringe; a plunger tip extension coupled to and slideable with said medial plunger tip portion; said plunger tip extension having a solid cross sectional area extending from a bottom portion of said plunger tip extension adjacent said medial portion to a substantially flat apex portion of said plunger tip extension; said plunger tip extension distally extending from said medial plunger tip portion and sized to pass through and extend beyond the open ended passageway of the syringe tip; a valve having a passageway defining a deal volume of said valve and defined by an internal sidewall of the valve coupleable to the syringe tip; and said plunger tip extension shaped to be complementally received within said passageway defining said dead volume of said valve and defined by said internal sidewall of said valve coupleable to the syringe tip for substantially displacing fluid and air from said dead volume of said valve.