| 发明名称 | Regulation of Wnt/beta-catenin signaling | ||
| 摘要 | A composition and method for detecting the ability of a compound to modulate the activity of LGR4, LGR5, or LGR6 receptors in a cell. LGR4, LGR5, and LGR6 are capable of activating the Wnt/β-catenin signaling system which plays essential roles in embryonic development and in the self-renewal and maintenance of adult stem cells. | ||
| 申请公布号 | US9057096(B2) | 申请公布日期 | 2015.06.16 |
| 申请号 | US201213475657 | 申请日期 | 2012.05.18 |
| 申请人 | Board of Regents of the University of Texas System | 发明人 | Liu Qingyun;Carmon Kendra;Gong Xing |
| 分类号 | C12Q1/66;G01N33/53;G01N33/50 | 主分类号 | C12Q1/66 |
| 代理机构 | Jackson Walker L.L.P. | 代理人 | Jackson Walker L.L.P. |
| 主权项 | 1. A method for identifying a compound having an ability to modulate activity of a receptor in a cell comprising the steps of: (a) contacting the compound with the receptor, the receptor having β-catenin activity and greater than 80% homology to an amino acid sequence encoded by the nucleic acid sequence SEQ ID NO:14; (b) determining if the activity of the receptor is modulated by measuring β-catenin activity in the cell; and (c) identifying the compound as a compound having an ability to modulate activity of the receptor in the cell if β-catenin activity in the cell is greater than the β-catenin activity in a cell which has not been exposed to the compound. | ||
| 地址 | Austin TX US | ||