| 发明名称 | Immunogenic composition | ||
| 摘要 | An immunogenic composition includes as an effective ingredient an antigen-adjuvant microparticle complex containing an antigen encapsulated in an adjuvant microparticle composed of an amphiphilic polymer(s) whose hydrophobic segment is a poly(hydroxy acid), or a particle composed of the antigen-adjuvant microparticle complex associated together, can induce a high immune response against the antigen even with a small amount of the antigen and a small number of doses, so that the immunogenic composition is useful as a vaccine effective for therapy and prophylaxis of infectious diseases, cancer and the like. | ||
| 申请公布号 | US9056095(B2) | 申请公布日期 | 2015.06.16 |
| 申请号 | US201013202336 | 申请日期 | 2010.02.26 |
| 申请人 | Toray Industries, Inc. | 发明人 | Nishio Reiji;Ida Nobuo |
| 分类号 | A61K39/395;A61K39/39;A61K47/48;A61K39/00 | 主分类号 | A61K39/395 |
| 代理机构 | DLA Piper LLP (US) | 代理人 | DLA Piper LLP (US) |
| 主权项 | 1. A method comprising administering an effective amount of an immunogenic composition comprising an antigen-adjuvant microparticle complex containing an antigen encapsulated in an adjuvant microparticle composed of an amphiphilic graft copolymer(s) comprising a poly(hydroxyl acid) as a hydrophobic graft segment and a polysaccharide as a hydrophilic backbone segment, wherein the number of poly(hydroxyl acid) graft chains of the amphiphilic graft copolymer is 2 to 50, to a living body, and inducing an immune response in the living body. | ||
| 地址 | JP | ||