摘要 |
<p>Disclosed are 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, their stereoisomers, tautomers, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent. Disclosed also are methods of using the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cellular proliferative, viral, autoimmune, cardiovascular, and central nevous system diseases.</p> |
申请人 |
NOVARTIS AG |
发明人 |
MACHAJEWSKI, TIMOTHY D.;SHAFER, CYNTHIA M.;MCBRIDE, CHRISTOPHER;ANTONIOS-MCCREA, WILLIAM;DOUGHAN, BRANDON M.;LEVINE, BARRY H.;XIA, YI;MCKENNA, MAUREEN;WANG, X. MICHAEL;MENDENHALL, KRIS;ZHOU, YASHEEN;GONG, BAOQING;GU, DAN;DOLAN, JOHN;TULINSKY, JOHN;BRINNER, KRISTIN;GAO, ZHENHAI;POON, DANIEL;BARSANTI, PAUL A.;LIN, XIAODONG;COSTALES, ABRAN;RICO, ALICE;BRAMMEIER, NATHAN;PICK, TERESA;RENHOWE, PAUL A. |