STABILIZED ALPHA-GALACTOSIDASE AND USES THEREOF

摘要

Multimeric protein structures comprising at least two alpha-galactosidase monomers being covalently linked to one another via a linking moiety are disclosed herein  as well a process for preparing same  and methods of treating Fabry disease via administration of a multimeric protein structure. The disclosed multimeric protein structures exhibit an improved performance  in terms of enhanced activity and/or a longer lasting activity under both lysosomal conditions and in a serum environment.