发明名称 |
Solid Salt Forms Of A Pyrrole Substituted 2-indolinone |
摘要 |
The present invention relates to solid salt forms of the 3-pyrrole substituted 2-indolinone compound 5-[5-fluoro-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-pirrolidin-1-yl-ethyl)-amide. It also relates to polymorphs of the phosphate salt of the amide. The invention further relates to the use of the salts and polymorphs in the treatment of protein kinase related disorders. |
申请公布号 |
US2015158849(A1) |
申请公布日期 |
2015.06.11 |
申请号 |
US201514620835 |
申请日期 |
2015.02.12 |
申请人 |
Zoetis LLC |
发明人 |
Hawley Michael;Sun Changquan Calvin |
分类号 |
C07D403/06 |
主分类号 |
C07D403/06 |
代理机构 |
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代理人 |
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主权项 |
1. A citrate salt of a base, wherein the base is 5-[5-fluoro-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-pyrrolidin-1-yl-ethyl)-amide. |
地址 |
Florham Park NJ US |