| 发明名称 |
USE OF POLYMERIC EXCIPIENTS FOR LYOPHILIZATION OR FREEZING OF PARTICLES |
| 摘要 |
Provided herein are use of polymeric excipients, specifically polyvinyl alcohols, optionally in conjunction with sugars, as cryoprotectants to prevent aggregation of PEG-containing particles. Also provided are PEG-containing particles comprising such polymeric excipients. |
| 申请公布号 |
US2015157722(A1) |
申请公布日期 |
2015.06.11 |
| 申请号 |
US201214362382 |
申请日期 |
2012.12.13 |
| 申请人 |
Abraxis BioScience, LLC |
发明人 |
Foss Willard;Shinde Rajesh |
| 分类号 |
A61K47/32;A61K31/337;A61K47/26;A61K9/50 |
主分类号 |
A61K47/32 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of preparing a lyophilized or frozen preparation of a composition comprising particles comprising a drug, wherein the particles are coated with PEG, the method comprising adding PVA to an aqueous composition comprising the particles and lyophilizing or freezing the aqueous composition. |
| 地址 |
Los Angeles CA US |
